Uses
Amitriptyline is approved by the Food and Drug Administration (FDA) for treating symptoms of depression. According to the manufacturer, amitriptyline is more effective for the treatment of endogenous depression (that which is caused by a genetic or biological factor) than for depression caused by external factors.
This medication is meant to be taken every day for the prevention of depressive symptoms. People usually have to take it for four to six weeks before seeing improvement in their symptoms.
Symptoms of depression can include:
- Sadness or hopelessness
- Loss of interest in activities
- Lack of motivation
- Crying
- Withdrawal from others
- Irritability
- Excessive sleeping or insomnia
- Changes in appetite
- Thinking about suicide
- Unexplained pain
Amitriptyline increases the action of norepinephrine and serotonin, neurotransmitters that play a role in modulating pain and mood. Specifically, amitriptyline prevents termination of the action of these neurotransmitters by preventing their uptake into membrane receptors.
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